Tissue Kallikrein Inhibits Retinal Neovascularization via the Cleavage of Vascular Endothelial Growth Factor-165 | Zendy

Shinsuke Nakamura | Zendy; Nobutaka Morimoto | Zendy; Kazuhiro Tsuruma | Zendy; Hiroshi Izuta | Zendy; Yoshika Yasuda | Zendy; Noriaki Kato | Zendy; Tsunehiko Ikeda | Zendy; Masamitsu Shimazawa | Zendy; Hideaki Hara | Zendy

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Tissue Kallikrein Inhibits Retinal Neovascularization via the Cleavage of Vascular Endothelial Growth Factor-165

Author(s) -

Shinsuke Nakamura,

Nobutaka Morimoto,

Kazuhiro Tsuruma,

Hiroshi Izuta,

Yoshika Yasuda,

Noriaki Kato,

Tsunehiko Ikeda,

Masamitsu Shimazawa,

Hideaki Hara

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.223594

Subject(s) - kallikrein , neovascularization , angiogenesis , retinal , vascular endothelial growth factor , vascular endothelial growth factor a , endocrinology , chemistry , medicine , ophthalmology , biochemistry , vegf receptors , enzyme

Tissue kallikrein, a widely used vasodilator for the treatment of hypertension and peripheral circulatory disorder, acts by releasing kinin, a potent vasodilator peptide. To identify the role of tissue kallikrein in retinal neovascularization, we investigated the antiangiogenic effect by using an in vitro and in vivo angiogenesis model.

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