Suppression of Endothelial P-Selectin Expression Contributes to Reduced Cell Trafficking in Females | Zendy

Inmaculada Concepción Villar | Zendy; Ramona S. Scotland | Zendy; Rayomand S. Khambata | Zendy; Melissa V. Chan | Zendy; Johan Duchêne | Zendy; André Luiz Franco Sampaio | Zendy; Mauro Perretti | Zendy; Adrian J. Hobbs | Zendy; Amrita Ahluwalia | Zendy

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Suppression of Endothelial P-Selectin Expression Contributes to Reduced Cell Trafficking in Females

Author(s) -

Inmaculada Concepción Villar,

Ramona S. Scotland,

Rayomand S. Khambata,

Melissa V. Chan,

Johan Duchêne,

André Luiz Franco Sampaio,

Mauro Perretti,

Adrian J. Hobbs,

Amrita Ahluwalia

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.223545

Subject(s) - microbiology and biotechnology , expression (computer science) , endothelial stem cell , p selectin , chemistry , biology , medicine , biochemistry , computer science , in vitro , platelet , platelet activation , programming language

Sex hormones underlie the lower incidence of cardiovascular disease in premenopausal women. Vascular inflammation is involved in the pathogenesis of several cardiovascular diseases and it has been reported that sex hormones modulate inflammatory responses but mechanisms responsible for these effects are not yet fully established. Herein, we assessed whether sex differences in leukocyte recruitment might exist and investigated the underlying mechanisms involved in this response.

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