Consequences of Epidermal Growth Factor Receptor (ErbB1) Loss for Vascular Smooth Muscle Cells From Mice With Targeted Deletion of ErbB1 | Zendy

Barbara Schreier | Zendy; Maria Döhler | Zendy; Sindy Rabe | Zendy; Bettina Schneider | Zendy; Gerald Schwerdt | Zendy; Stefanie Ruhs | Zendy; Maria Sibilia | Zendy; Michael Gotthardt | Zendy; Michael Gekle | Zendy; Claudia Großmann | Zendy

Open Access

Consequences of Epidermal Growth Factor Receptor (ErbB1) Loss for Vascular Smooth Muscle Cells From Mice With Targeted Deletion of ErbB1

Author(s) -

Barbara Schreier,

Maria Döhler,

Sindy Rabe,

Bettina Schneider,

Gerald Schwerdt,

Stefanie Ruhs,

Maria Sibilia,

Michael Gotthardt,

Michael Gekle,

Claudia Großmann

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.223537

Subject(s) - vascular smooth muscle , epidermal growth factor receptor , endocrinology , epidermal growth factor , medicine , autocrine signalling , microbiology and biotechnology , signal transduction , biology , chemistry , receptor , smooth muscle

Pathophysiological effects of the epidermal growth factor receptor (EGFR or ErbB1) include vascular remodeling. EGFR transactivation is proposed to contribute significantly to heterologous signaling and remodeling in vascular smooth muscle cells (VSMC).

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