Endothelial Microparticle Formation by Angiotensin II Is Mediated via Ang II Receptor Type I/NADPH Oxidase/ Rho Kinase Pathways Targeted to Lipid Rafts | Zendy

Dylan Burger | Zendy; Augusto C. Montezano | Zendy; Nobuhiro Nishigaki | Zendy; Ying He | Zendy; Anthony Carter | Zendy; Rhian M. Touyz | Zendy

Open Access

Endothelial Microparticle Formation by Angiotensin II Is Mediated via Ang II Receptor Type I/NADPH Oxidase/ Rho Kinase Pathways Targeted to Lipid Rafts

Author(s) -

Dylan Burger,

Augusto C. Montezano,

Nobuhiro Nishigaki,

Ying He,

Anthony Carter,

Rhian M. Touyz

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.222703

Subject(s) - nadph oxidase , angiotensin ii , microparticle , chemistry , microbiology and biotechnology , lipid raft , caveolae , apocynin , proinflammatory cytokine , inflammation , oxidative stress , signal transduction , receptor , biology , biochemistry , immunology , astrobiology

Circulating microparticles are increased in cardiovascular disease and may themselves promote oxidative stress and inflammation. Molecular mechanisms underlying their formation and signaling are unclear. We investigated the role of reactive oxygen species (ROS), Rho kinase, and lipid rafts in microparticle formation and examined their functional significance in endothelial cells (ECs).

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