Roles of Prostaglandin E 2 –EP3/EP4 Receptor Signaling in the Enhancement of Lymphangiogenesis During Fibroblast Growth Factor-2–Induced Granulation Formation | Zendy

Kanako Hosono | Zendy; Tatsunori Suzuki | Zendy; Hideaki Tamaki | Zendy; Hiroyuki Sakagami | Zendy; Izumi Hayashi | Zendy; Shuh Narumiya | Zendy; Kari Alitalo | Zendy; Masataka Majima | Zendy

Open Access

Roles of Prostaglandin E ₂ –EP3/EP4 Receptor Signaling in the Enhancement of Lymphangiogenesis During Fibroblast Growth Factor-2–Induced Granulation Formation

Author(s) -

Kanako Hosono,

Tatsunori Suzuki,

Hideaki Tamaki,

Hiroyuki Sakagami,

Izumi Hayashi,

Shuh Narumiya,

Kari Alitalo,

Masataka Majima

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.222356

Subject(s) - lymphangiogenesis , matrigel , angiogenesis , cancer research , inflammation , vascular endothelial growth factor c , vascular endothelial growth factor , microbiology and biotechnology , endocrinology , vascular endothelial growth factor a , chemistry , medicine , biology , cancer , metastasis , vegf receptors

One of the hallmarks of inflammation is lymphangiogesis that drains the interstitial fluids. During chronic inflammation, angiogenesis is induced by a variety of inflammatory mediators, such as prostaglandins (PGs). However, it remains unknown whether they enhance lymphangiogenesis. We examined the roles of cyclooxygenase-2 (COX-2) and PGE2 receptor signaling in enhancement of lymphangiogenesis during proliferative inflammation.

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