Epigenetic Regulation of Vascular Smooth Muscle Cell Proliferation and Neointima Formation by Histone Deacetylase Inhibition | Zendy

Hannes M. Findeisen | Zendy; Florence Gizard | Zendy; Yue Zhao | Zendy; Qing Hua | Zendy; Elizabeth B. Heywood | Zendy; Karrie L. Jones | Zendy; Dianne Cohn | Zendy; Dennis Bruemmer | Zendy

Open Access

Epigenetic Regulation of Vascular Smooth Muscle Cell Proliferation and Neointima Formation by Histone Deacetylase Inhibition

Author(s) -

Hannes M. Findeisen,

Florence Gizard,

Yue Zhao,

Qing Hua,

Elizabeth B. Heywood,

Karrie L. Jones,

Dianne Cohn,

Dennis Bruemmer

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.221952

Subject(s) - cyclin d1 , histone deacetylase , neointima , histone deacetylase 5 , microbiology and biotechnology , hdac11 , cancer research , biology , cyclin a , vascular smooth muscle , retinoblastoma protein , cell growth , hdac4 , histone deacetylase 2 , trichostatin a , cell cycle , histone , cell , biochemistry , medicine , endocrinology , gene , restenosis , smooth muscle , stent

Proliferation of smooth muscle cells (SMC) in response to vascular injury is central to neointimal vascular remodeling. There is accumulating evidence that histone acetylation constitutes a major epigenetic modification for the transcriptional control of proliferative gene expression; however, the physiological role of histone acetylation for proliferative vascular disease remains elusive.

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