RhoA-Mediated Signaling in Notch-Induced Senescence-Like Growth Arrest and Endothelial Barrier Dysfunction | Zendy

Deepak Venkatesh | Zendy; Natalie C. Fredette | Zendy; Bahman Rostama | Zendy; Yuefeng Tang | Zendy; Calvin Vary | Zendy; Lucy Liaw | Zendy; Sumithra Urs | Zendy

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RhoA-Mediated Signaling in Notch-Induced Senescence-Like Growth Arrest and Endothelial Barrier Dysfunction

Author(s) -

Deepak Venkatesh,

Natalie C. Fredette,

Bahman Rostama,

Yuefeng Tang,

Calvin Vary,

Lucy Liaw,

Sumithra Urs

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.221945

Subject(s) - microbiology and biotechnology , notch signaling pathway , adherens junction , myosin light chain kinase , rhoa , senescence , biology , hes3 signaling axis , notch proteins , signal transduction , sprouting angiogenesis , endothelial stem cell , phosphorylation , chemistry , cell , cadherin , biochemistry , in vitro

Notch signaling has a critical role in vascular development and morphogenesis. Activation of Notch in endothelial cells led to a senescence-like phenotype with loss of barrier function. Our objective was to understand the molecular pathways mediating this phenotype.

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