Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography–Computed Tomography | Zendy

Matthias Nahrendorf | Zendy; Edmund J. Keliher | Zendy; Brett Marinelli | Zendy; Florian Leuschner | Zendy; Clinton S. Robbins | Zendy; Robert E. Gerszten | Zendy; Mikaël J. Pittet | Zendy; Filip K. Świrski | Zendy; Ralph Weissleder | Zendy

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Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography–Computed Tomography

Author(s) -

Matthias Nahrendorf,

Edmund J. Keliher,

Brett Marinelli,

Florian Leuschner,

Clinton S. Robbins,

Robert E. Gerszten,

Mikaël J. Pittet,

Filip K. Świrski,

Ralph Weissleder

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.221499

Subject(s) - positron emission tomography , macrophage , inflammation , in vivo , aorta , monocyte , flow cytometry , medicine , molecular imaging , ex vivo , pathology , tomography , radiology , nuclear medicine , chemistry , in vitro , biology , immunology , biochemistry , microbiology and biotechnology

Current management of aortic aneurysms (AAs) relies primarily on size criteria to determine whether invasive repair is indicated to preempt rupture. We hypothesized that emerging molecular imaging tools could be used to more sensitively gauge local inflammation. Because macrophages are key effector cells that destabilize the extracellular matrix in the arterial wall, it seemed likely that they would represent suitable imaging targets. We here aimed to develop and validate macrophage-targeted nanoparticles labeled with fluorine-18 ((18)F) for positron emission tomography-computed tomography (PET-CT) detection of inflammation in AAs.

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