Detection of Hypoxia by [ 18 F]EF5 in Atherosclerotic Plaques in Mice | Zendy

Johanna M. U. Silvola | Zendy; Antti Saraste | Zendy; Sarita Forsbäck | Zendy; V. Laine | Zendy; Pekka Saukko | Zendy; Suvi E. Hein | Zendy; Seppo YläHerttuala | Zendy; Anne Roivainen | Zendy; Juhani Knuuti | Zendy

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Detection of Hypoxia by [ ¹⁸ F]EF5 in Atherosclerotic Plaques in Mice

Author(s) -

Johanna M. U. Silvola,

Antti Saraste,

Sarita Forsbäck,

V. Laine,

Pekka Saukko,

Suvi E. Hein,

Seppo YläHerttuala,

Anne Roivainen,

Juhani Knuuti

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.221440

Subject(s) - hypoxia (environmental) , immunostaining , chemistry , immunohistochemistry , biodistribution , pathology , apolipoprotein b , lipoprotein , blood vessel , cholesterol , endocrinology , biology , medicine , biochemistry , in vitro , oxygen , organic chemistry

Atherosclerotic plaques with large lipid cores and inflammation contain regions of hypoxia. We examined the uptake of 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide ([18F]EF5), a specific marker of hypoxia labeled for positron emission tomography, in mouse atherosclerotic plaques.

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