Flanking Recipient Vasculature, Not Circulating Progenitor Cells, Contributes to Endothelium and Smooth Muscle in Murine Allograft Vasculopathy | Zendy

Mette K. Hagensen | Zendy; Jeong Shim | Zendy; Erling Falk | Zendy; Jacob Fog Bentzon | Zendy

Open Access

Flanking Recipient Vasculature, Not Circulating Progenitor Cells, Contributes to Endothelium and Smooth Muscle in Murine Allograft Vasculopathy

Author(s) -

Mette K. Hagensen,

Jeong Shim,

Erling Falk,

Jacob Fog Bentzon

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.221184

Subject(s) - isograft , progenitor cell , transplantation , biology , endothelium , progenitor , blood vessel , microbiology and biotechnology , immunology , pathology , stem cell , medicine , endocrinology

The prevailing view assumes that circulating endothelial and smooth muscle progenitor cells participate in allograft vasculopathy (AV), although the seminal studies in the field were not designed to distinguish between circulating and migrating cells of recipient origin. We developed a double-transplantation technique to overcome this problem and reinvestigated the origin of endothelial cells (ECs) and smooth muscle cells (SMCs) in murine AV.

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