Smooth Muscle Cell Differentiation In Vitro | Zendy

Changqing Xie | Zendy; Raquel P. Ritchie | Zendy; Huarong Huang | Zendy; Jifeng Zhang | Zendy; Yisheng Chen | Zendy

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Smooth Muscle Cell Differentiation In Vitro

Author(s) -

Changqing Xie,

Raquel P. Ritchie,

Huarong Huang,

Jifeng Zhang,

Yisheng Chen

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.221101

Subject(s) - in vitro , cellular differentiation , biology , microbiology and biotechnology , phenotype , stem cell , cell , neuroscience , computational biology , genetics , gene

Development of in vitro models by which to study smooth muscle cell (SMC) differentiation has been hindered by some peculiarities intrinsic to these cells, namely their different embryological origins and their ability to undergo phenotypic modulation in cell culture. Although many in vitro models are available for studying SMC differentiation, careful consideration should be taken so that the model chosen fits the questions being posed. In this review, we summarize several well-established in vitro models available to study SMC differentiation from stem cells and outline novel mechanisms recently identified as underlying SMC differentiation programs.

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