Mast Cell Activation In Vivo Impairs the Macrophage Reverse Cholesterol Transport Pathway in the Mouse | Zendy

Miriam LeeRueckert | Zendy; Reija Silvennoinen | Zendy; Noemí Rotllán | Zendy; Ilona Judström | Zendy; Francisco BlancoVaca | Zendy; Jari Metso | Zendy; Matti Jauhiainen | Zendy; Petri T. Kovanen | Zendy; Joan Carles EscolàGil | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mast Cell Activation In Vivo Impairs the Macrophage Reverse Cholesterol Transport Pathway in the Mouse

Author(s) -

Miriam LeeRueckert,

Reija Silvennoinen,

Noemí Rotllán,

Ilona Judström,

Francisco BlancoVaca,

Jari Metso,

Matti Jauhiainen,

Petri T. Kovanen,

Joan Carles EscolàGil

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.221069

Subject(s) - in vivo , mast cell , microbiology and biotechnology , macrophage , foam cell , cholesterol , chemistry , reverse cholesterol transport , biology , immunology , in vitro , biochemistry , lipoprotein

Chymase released by activated mast cells degrades high-density lipoproteins. We evaluated whether local activation of mast cells would attenuate cholesterol efflux from neighboring macrophage foam cells, thereby disrupting the entire in vivo pathway of macrophage-specific reverse cholesterol transport (RCT).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research