Decorin GAG Synthesis and TGF-β Signaling Mediate Ox-LDL–Induced Mineralization of Human Vascular Smooth Muscle Cells | Zendy

Jianyun Yan | Zendy; Sally E. Stringer | Zendy; Andrew Hamilton | Zendy; Valentine Charlton-Menys | Zendy; C Götting | Zendy; Benjamin Müller | Zendy; Daniel Aeschlimann | Zendy; M. Yvonne Alexander | Zendy

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Decorin GAG Synthesis and TGF-β Signaling Mediate Ox-LDL–Induced Mineralization of Human Vascular Smooth Muscle Cells

Author(s) -

Jianyun Yan,

Sally E. Stringer,

Andrew Hamilton,

Valentine Charlton-Menys,

C Götting,

Benjamin Müller,

Daniel Aeschlimann,

M. Yvonne Alexander

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.220749

Subject(s) - decorin , vascular smooth muscle , smooth muscle , transforming growth factor , chemistry , microbiology and biotechnology , signal transduction , myocyte , biochemistry , extracellular matrix , biology , endocrinology , proteoglycan

Decorin and oxidized low-density lipoprotein (Ox-LDL) independently induce osteogenic differentiation of vascular smooth muscle cells (VSMCs). We aimed to determine whether decorin glycosaminoglycan (GAG) chain synthesis contributes to Ox-LDL-induced differentiation and calcification of human VSMCs in vitro.

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