Activation of Aryl Hydrocarbon Receptor Induces Vascular Inflammation and Promotes Atherosclerosis in Apolipoprotein E−/− Mice | Zendy

Dalei Wu | Zendy; Noriko Nishimura | Zendy; Victoria Kuo | Zendy; Oliver Fiehn | Zendy; Sevini Shahbaz | Zendy; Laura S. Van Winkle | Zendy; Fumio Matsumura | Zendy; Christoph F.A. Vogel | Zendy

Open Access

Activation of Aryl Hydrocarbon Receptor Induces Vascular Inflammation and Promotes Atherosclerosis in Apolipoprotein E−/− Mice

Author(s) -

Dalei Wu,

Noriko Nishimura,

Victoria Kuo,

Oliver Fiehn,

Sevini Shahbaz,

Laura S. Van Winkle,

Fumio Matsumura,

Christoph F.A. Vogel

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.220202

Subject(s) - aryl hydrocarbon receptor , inflammation , apolipoprotein e , macrophage , chemistry , receptor , chemokine , endocrinology , medicine , immunology , biology , in vitro , biochemistry , transcription factor , disease , gene

Exposure to dioxins has been shown to contribute to the development of inflammatory diseases, such as atherosclerosis. Macrophage-mediated inflammation is a critical event in the initiation of atherosclerosis. Previously, we showed that treatment of macrophages with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to aryl hydrocarbon receptor (AhR)-dependent activation of inflammatory mediators and the formation of cholesterol-laden foam cells. However, the mechanisms responsible for the formation of atherosclerotic lesions mediated through AhR have not been identified.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research