Telomerase Activation in Atherosclerosis and Induction of Telomerase Reverse Transcriptase Expression by Inflammatory Stimuli in Macrophages | Zendy

Florence Gizard | Zendy; Elizabeth B. Heywood | Zendy; Hannes M. Findeisen | Zendy; Yue Zhao | Zendy; Karrie L. Jones | Zendy; Céline Cudejko | Zendy; Ginell R. Post | Zendy; Bart Staels | Zendy; Dennis Bruemmer | Zendy

Open Access

Telomerase Activation in Atherosclerosis and Induction of Telomerase Reverse Transcriptase Expression by Inflammatory Stimuli in Macrophages

Author(s) -

Florence Gizard,

Elizabeth B. Heywood,

Hannes M. Findeisen,

Yue Zhao,

Karrie L. Jones,

Céline Cudejko,

Ginell R. Post,

Bart Staels,

Dennis Bruemmer

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.219808

Subject(s) - telomerase , telomerase reverse transcriptase , biology , chromatin immunoprecipitation , inflammation , microbiology and biotechnology , protein subunit , chromatin remodeling , gene expression , cancer research , immunology , promoter , gene , genetics

Telomerase serves as a critical regulator of tissue renewal. Although telomerase activity is inducible in response to various environmental cues, it remains unknown whether telomerase is activated during the inflammatory remodeling underlying atherosclerosis formation. To address this question, we investigated in the present study the regulation of telomerase in macrophages and during atherosclerosis development in low-density lipoprotein receptor-deficient mice.

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