H 2 O 2 Regulation of Vascular Function Through sGC mRNA Stabilization by HuR | Zendy

Abel Martín-Garrido | Zendy; Marta González-Ramos | Zendy; Mercedes Griera | Zendy; Brenda Guijarro | Zendy; Jorge B. CannataAndía | Zendy; Diego Rodrı́guez-Puyol | Zendy; Manuel RodríguezPuyol | Zendy; Marta Saura | Zendy

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H ₂ O ₂ Regulation of Vascular Function Through sGC mRNA Stabilization by HuR

Author(s) -

Abel Martín-Garrido,

Marta González-Ramos,

Mercedes Griera,

Brenda Guijarro,

Jorge B. CannataAndía,

Diego Rodrı́guez-Puyol,

Manuel RodríguezPuyol,

Marta Saura

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.219725

Subject(s) - sodium nitroprusside , downregulation and upregulation , vascular smooth muscle , messenger rna , soluble guanylyl cyclase , gene silencing , nitric oxide , microbiology and biotechnology , cytosol , protein subunit , chemistry , endogeny , catalase , biology , endocrinology , biochemistry , guanylate cyclase , oxidative stress , enzyme , smooth muscle , gene

Hydrogen peroxide (H(2)O(2)) is an important mediator in the vasculature, but its role in the regulation of soluble guanylate cyclase (sGC) activity and expression is not completely understood. The aim of this study was to test the effect of H(2)O(2) on sGC expression and function and to explore the molecular mechanism involved.

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