Systemic Markers of Interferon-γ–Mediated Immune Activation and Long-Term Prognosis in Patients With Stable Coronary Artery Disease | Zendy

Eva Ringdal Pedersen | Zendy; Øivind Midttun | Zendy; Per Magne Ueland | Zendy; Hall Schartum-Hansen | Zendy; Reinhard Seifert | Zendy; Jannicke Igland | Zendy; Jan Erik Nordrehaug | Zendy; Marta Ebbing | Zendy; G.F.T. Svingen | Zendy; Øyvind Bleie | Zendy; R J ten Berge | Zendy; Ottar Nygård | Zendy

Open Access

Systemic Markers of Interferon-γ–Mediated Immune Activation and Long-Term Prognosis in Patients With Stable Coronary Artery Disease

Author(s) -

Eva Ringdal Pedersen,

Øivind Midttun,

Per Magne Ueland,

Hall Schartum-Hansen,

Reinhard Seifert,

Jannicke Igland,

Jan Erik Nordrehaug,

Marta Ebbing,

G.F.T. Svingen,

Øyvind Bleie,

R J ten Berge,

Ottar Nygård

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.219329

Subject(s) - neopterin , medicine , kynurenine , hazard ratio , unstable angina , coronary artery disease , stable angina , cardiology , inflammation , interferon gamma , proportional hazards model , gastroenterology , myocardial infarction , tryptophan , confidence interval , cytokine , biochemistry , chemistry , amino acid

Interferon γ (IFN-γ) is centrally involved in atherosclerosis-related inflammation, but its activity cannot be reliably assessed by systemic measurements. In activated macrophages, IFN-γ stimulates production of neopterin and conversion of tryptophan to kynurenine. We evaluated the relationships of plasma neopterin and plasma kynurenine:tryptophan ratio (KTR) to long-term prognosis in patients with stable angina pectoris and angiographically verified significant coronary artery disease.

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