Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo | Zendy

Robin Ray | Zendy; Colin E. Murdoch | Zendy; Minshu Wang | Zendy; Célio X.C. Santos | Zendy; Min Zhang | Zendy; Sara P. Alom-Ruiz | Zendy; Narayana Anilkumar | Zendy; Alexandre Ouattara | Zendy; Alison Cave | Zendy; Simon Walker | Zendy; David J. Grieve | Zendy; Rebecca L. Charles | Zendy; Philip Eaton | Zendy; Alison C. Brewer | Zendy; Ajay M. Shah | Zendy

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Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

Author(s) -

Robin Ray,

Colin E. Murdoch,

Minshu Wang,

Célio X.C. Santos,

Min Zhang,

Sara P. Alom-Ruiz,

Narayana Anilkumar,

Alexandre Ouattara,

Alison Cave,

Simon Walker,

David J. Grieve,

Rebecca L. Charles,

Philip Eaton,

Alison C. Brewer,

Ajay M. Shah

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.219238

Subject(s) - nox4 , vasodilation , nadph oxidase , in vivo , blood pressure , medicine , endothelium , blood vessel , chemistry , cardiology , pharmacology , endocrinology , biology , oxidative stress , microbiology and biotechnology

Increased reactive oxygen species (ROS) production is involved in the pathophysiology of endothelial dysfunction. NADPH oxidase-4 (Nox4) is a ROS-generating enzyme expressed in the endothelium, levels of which increase in pathological settings. Recent studies indicate that it generates predominantly hydrogen peroxide (H(2)O(2)), but its role in vivo remains unclear.

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