A Selective Matrix Metalloproteinase-12 Inhibitor Retards Atherosclerotic Plaque Development in Apolipoprotein E–Knockout Mice | Zendy

Jason L. Johnson | Zendy; Laurent Devel | Zendy; Bertrand Czarny | Zendy; Sarah J. George | Zendy; Christopher L. Jackson | Zendy; Vassilis Rogakos | Zendy; Fabrice Beau | Zendy; Athanasios Yiotakis | Zendy; Andrew C. Newby | Zendy; Vincent Dive | Zendy

Open Access

A Selective Matrix Metalloproteinase-12 Inhibitor Retards Atherosclerotic Plaque Development in Apolipoprotein E–Knockout Mice

Author(s) -

Jason L. Johnson,

Laurent Devel,

Bertrand Czarny,

Sarah J. George,

Christopher L. Jackson,

Vassilis Rogakos,

Fabrice Beau,

Athanasios Yiotakis,

Andrew C. Newby,

Vincent Dive

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.219147

Subject(s) - fibrous cap , knockout mouse , apolipoprotein e , matrix metalloproteinase , macrophage , apolipoprotein b , apoptosis , in vivo , foam cell , vulnerable plaque , endocrinology , cancer research , biology , medicine , chemistry , in vitro , biochemistry , receptor , cholesterol , microbiology and biotechnology , disease

Matrix metalloproteinase (MMP)-12 has been implicated in plaque progression and instability and is also amenable to selective inhibition. In this study, we investigated the influence of a greater than 10-fold selective synthetic MMP-12 inhibitor on plaque progression in the apolipoprotein E knockout mouse model of atherosclerosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research