Telomerase Deficiency in Bone Marrow–Derived Cells Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm Formation | Zendy

Hannes M. Findeisen | Zendy; Florence Gizard | Zendy; Yue Zhao | Zendy; Dianne Cohn | Zendy; Elizabeth B. Heywood | Zendy; Karrie L. Jones | Zendy; David H. Lovett | Zendy; Deborah A. Howatt | Zendy; Alan Daugherty | Zendy; Dennis Bruemmer | Zendy

Open Access

Telomerase Deficiency in Bone Marrow–Derived Cells Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm Formation

Author(s) -

Hannes M. Findeisen,

Florence Gizard,

Yue Zhao,

Dianne Cohn,

Elizabeth B. Heywood,

Karrie L. Jones,

David H. Lovett,

Deborah A. Howatt,

Alan Daugherty,

Dennis Bruemmer

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.218545

Subject(s) - bone marrow , ldl receptor , angiotensin ii , telomerase , endocrinology , medicine , chemistry , lipoprotein , immunology , receptor , cholesterol , biochemistry , gene

Abdominal aortic aneurysms (AAA) are an age-related vascular disease and an important cause of morbidity and mortality. In this study, we sought to determine whether the catalytic component of telomerase, telomerase reverse transcriptase (TERT), modulates angiotensin (Ang) II-induced AAA formation.

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