Primary Monocytes Regulate Endothelial Cell Survival Through Secretion of Angiopoietin-1 and Activation of Endothelial Tie2 | Zendy

Shai Y. Schubert | Zendy; Alejandro Benarroch | Zendy; Juan Monter-Solans | Zendy; Elazer R. Edelman | Zendy

Open Access

Primary Monocytes Regulate Endothelial Cell Survival Through Secretion of Angiopoietin-1 and Activation of Endothelial Tie2

Author(s) -

Shai Y. Schubert,

Alejandro Benarroch,

Juan Monter-Solans,

Elazer R. Edelman

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.218255

Subject(s) - angiopoietin receptor , angiopoietin , endothelial stem cell , microbiology and biotechnology , vascular endothelial growth inhibitor , vascular endothelial growth factor b , endothelium , vascular endothelial growth factor a , monocyte , tumor necrosis factor alpha , biology , angiogenesis , cancer research , vascular endothelial growth factor , immunology , endocrinology , biochemistry , in vitro , vegf receptors

Monocyte recruitment and interaction with the endothelium is imperative to vascular recovery. Tie2 plays a key role in endothelial health and vascular remodeling. We studied monocyte-mediated Tie2/angiopoietin signaling following interaction of primary monocytes with endothelial cells and its role in endothelial cell survival.

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