Inherited Human gp91 phox Deficiency Is Associated With Impaired Isoprostane Formation and Platelet Dysfunction | Zendy

Pasquale Pignatelli | Zendy; Roberto Carnevale | Zendy; Serena Di Santo | Zendy; Simona Bartimoccia | Zendy; Valerio Sanguigni | Zendy; Luisa Lenti | Zendy; Andrea Finocchi | Zendy; Loredana Mendolicchio | Zendy; Anna Rosa Soresina | Zendy; Alessandro Plebani | Zendy; Francesco Violi | Zendy

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Inherited Human gp91 ^phox Deficiency Is Associated With Impaired Isoprostane Formation and Platelet Dysfunction

Author(s) -

Pasquale Pignatelli,

Roberto Carnevale,

Serena Di Santo,

Simona Bartimoccia,

Valerio Sanguigni,

Luisa Lenti,

Andrea Finocchi,

Loredana Mendolicchio,

Anna Rosa Soresina,

Alessandro Plebani,

Francesco Violi

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.217885

Subject(s) - platelet , thromboxane a2 , medicine , arachidonic acid , endocrinology , chemistry , platelet activation , nadph oxidase , isoprostane , thrombus , aspirin , thromboxane , cyclooxygenase , thromboxane a synthase , oxidative stress , biochemistry , enzyme , lipid peroxidation

Platelet isoprostane 8-ISO-prostaglandin F2α (8-iso-PGF2α), a proaggregating molecule, is believed to derive from nonenzymatic oxidation of arachidonic acid. We hypothesized that NADPH is implicated in isoprostane formation and platelet activation.

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