Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis | Zendy

Liya Yin | Zendy; Huiyan Ma | Zendy; Xuemei Ge | Zendy; Peter A. Edwards | Zendy; Yanqiao Zhang | Zendy

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Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

Author(s) -

Liya Yin,

Huiyan Ma,

Xuemei Ge,

Peter A. Edwards,

Yanqiao Zhang

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.217828

Subject(s) - endocrinology , medicine , hepatocyte nuclear factors , hepatocyte nuclear factor 4 , lipogenesis , triglyceride , lipid metabolism , biology , cholesterol , gene expression , biochemistry , transcription factor , gene , nuclear receptor

Loss-of-function mutations in human hepatocyte nuclear factor 4α (HNF4α) are associated with maturity-onset diabetes of the young and lipid disorders. However, the mechanisms underlying the lipid disorders are poorly understood. In this study, we determined the effect of acute loss or augmentation of hepatic HNF4α function on lipid homeostasis.

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