Human CD34 + /KDR + Cells Are Generated From Circulating CD34 + Cells After Immobilization on Activated Platelets
Author(s) -
Hetty C. de Boer,
Marcel M.C. Hovens,
Annemarie M. van OeverenRietdijk,
Jaapjan D. Snoep,
Eelco J.P. de Koning,
Jouke T. Tamsma,
Menno V. Huisman,
Ton J. Rabelink,
Anton Jan van Zonneveld
Publication year - 2010
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.110.216879
Subject(s) - cd34 , progenitor cell , bone marrow , haematopoiesis , platelet , chemistry , population , endothelial stem cell , stem cell , biology , endocrinology , medicine , microbiology and biotechnology , cancer research , immunology , biochemistry , in vitro , environmental health
The presence of kinase-insert domain-containing receptor (KDR) on circulating CD34+ cells is assumed to be indicative for the potential of these cells to support vascular maintenance and repair. However, in bone marrow and in granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood, less than 0.5% of CD34+ cells co-express KDR. Therefore, we studied whether CD34+/KDR+ cells are generated in the peripheral circulation.
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