The Prostaglandin E 2 Receptor EP4 Is Expressed by Human Platelets and Potently Inhibits Platelet Aggregation and Thrombus Formation | Zendy

Sonia Philipose | Zendy; Viktória Kónya | Zendy; Ivana Sreckovic | Zendy; Gunther Marsche | Zendy; Irmgard Th. Lippe | Zendy; Bernhard A. Peskar | Zendy; Ákos Heinemann | Zendy; Rufina Schuligoi | Zendy

Open Access

The Prostaglandin E ₂ Receptor EP4 Is Expressed by Human Platelets and Potently Inhibits Platelet Aggregation and Thrombus Formation

Author(s) -

Sonia Philipose,

Viktória Kónya,

Ivana Sreckovic,

Gunther Marsche,

Irmgard Th. Lippe,

Bernhard A. Peskar,

Ákos Heinemann,

Rufina Schuligoi

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.216374

Subject(s) - prostaglandin e2 receptor , receptor , chemistry , platelet , agonist , thromboxane , prostaglandin e , platelet activation , receptor antagonist , thromboxane a2 , prostaglandin , pharmacology , protease activated receptor , platelet aggregation inhibitor , endocrinology , medicine , antagonist , biochemistry , biology , thrombin

Low concentrations of prostaglandin (PG) E(2) enhance platelet aggregation, whereas high concentrations inhibit it. The effects of PGE(2) are mediated through 4 G protein-coupled receptors, termed E-type prostaglindin (EP) receptor EP1, EP2, EP3, and EP4. The platelet-stimulating effect of PGE(2) has been suggested to involve EP3 receptors. Here we analyzed the receptor usage relating to the inhibitory effect of PGE(2).

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