Influence of Apolipoprotein A-I Domain Structure on Macrophage Reverse Cholesterol Transport in Mice | Zendy

Eric T. Alexander | Zendy; Charulatha Vedhachalam | Zendy; Sandhya Sankaranarayanan | Zendy; Margarita de la Llera-Moya | Zendy; George H. Rothblat | Zendy; Daniel J. Rader | Zendy; Michael C. Phillips | Zendy

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Influence of Apolipoprotein A-I Domain Structure on Macrophage Reverse Cholesterol Transport in Mice

Author(s) -

Eric T. Alexander,

Charulatha Vedhachalam,

Sandhya Sankaranarayanan,

Margarita de la Llera-Moya,

George H. Rothblat,

Daniel J. Rader,

Michael C. Phillips

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.216226

Subject(s) - reverse cholesterol transport , macrophage , cholesterol , apolipoprotein b , apolipoprotein e , domain (mathematical analysis) , chemistry , microbiology and biotechnology , biology , medicine , biochemistry , lipoprotein , mathematics , disease , in vitro , mathematical analysis

The goal of this study was to determine the influence of apolipoprotein A-I (apoA-I) tertiary structure domain properties on the antiatherogenic properties of the protein. Two chimeric hybrids with the N-terminal domains swapped (human-mouse apoA-I and mouse-human apoA-I) were expressed in apoA-I-null mice with adeno-associated virus (AAV) and used to study macrophage reverse cholesterol transport (RCT) in vivo.

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