Macrophage Adipose Triglyceride Lipase Deficiency Attenuates Atherosclerotic Lesion Development in Low-Density Lipoprotein Receptor Knockout Mice | Zendy

Bart Lammers | Zendy; Prakash G. Chandak | Zendy; Elma Aflaki | Zendy; Gijs H.M. van Puijvelde | Zendy; Branislav Radović | Zendy; Reeni B. Hildebrand | Zendy; Illiana Meurs | Zendy; Ruud Out | Zendy; Johan Kuiper | Zendy; Theo J.C. van Berkel | Zendy; Dagmar Kolb | Zendy; Guenter Haemmerle | Zendy; Rudolf Zechner | Zendy; Sanja LevakFrank | Zendy; Miranda Van Eck | Zendy; Dagmar Kratky | Zendy

Open Access

Macrophage Adipose Triglyceride Lipase Deficiency Attenuates Atherosclerotic Lesion Development in Low-Density Lipoprotein Receptor Knockout Mice

Author(s) -

Bart Lammers,

Prakash G. Chandak,

Elma Aflaki,

Gijs H.M. van Puijvelde,

Branislav Radović,

Reeni B. Hildebrand,

Illiana Meurs,

Ruud Out,

Johan Kuiper,

Theo J.C. van Berkel,

Dagmar Kolb,

Guenter Haemmerle,

Rudolf Zechner,

Sanja LevakFrank,

Miranda Van Eck,

Dagmar Kratky

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.215814

Subject(s) - adipose triglyceride lipase , medicine , endocrinology , triglyceride , chemistry , ldl receptor , knockout mouse , macrophage , receptor , lipoprotein , biology , cholesterol , biochemistry , in vitro

The consequences of macrophage triglyceride (TG) accumulation on atherosclerosis have not been studied in detail so far. Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme for the initial step in TG hydrolysis. Because ATGL knockout (KO) mice exhibit massive TG accumulation in macrophages, we used ATGL KO mice to study the effects of macrophage TG accumulation on atherogenesis.

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