Worsening of Diet-Induced Atherosclerosis in a New Model of Transgenic Rabbit Expressing the Human Plasma Phospholipid Transfer Protein | Zendy

David Masson | Zendy; Valérie Deckert | Zendy; Thomas Gautier | Zendy; Alexis Klein | Zendy; Catherine Desrumaux | Zendy; Céline Viglietta | Zendy; Jean-Paul Paı̈s de Barros | Zendy; Naïg Le Guern | Zendy; Jacques Grober | Zendy; Jérôme Labbé | Zendy; Franck Ménétrier | Zendy; Pierre-Jean Ripoll | Zendy; Mathieu LerouxCoyau | Zendy; Geneviève Jolivet | Zendy; LouisMarie Houdebine | Zendy; Laurent Lagrost | Zendy

Open Access

Worsening of Diet-Induced Atherosclerosis in a New Model of Transgenic Rabbit Expressing the Human Plasma Phospholipid Transfer Protein

Author(s) -

David Masson,

Valérie Deckert,

Thomas Gautier,

Alexis Klein,

Catherine Desrumaux,

Céline Viglietta,

Jean-Paul Paı̈s de Barros,

Naïg Le Guern,

Jacques Grober,

Jérôme Labbé,

Franck Ménétrier,

Pierre-Jean Ripoll,

Mathieu LerouxCoyau,

Geneviève Jolivet,

LouisMarie Houdebine,

Laurent Lagrost

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.215756

Subject(s) - phospholipid transfer protein , medicine , apolipoprotein b , endocrinology , cholesterol , phospholipid , transgene , lipoprotein , genetically modified mouse , chemistry , plant lipid transfer proteins , cholesterylester transfer protein , apolipoprotein e , biology , biochemistry , gene , disease , membrane

Plasma phospholipid transfer protein (PLTP) is involved in intravascular lipoprotein metabolism. PLTP is known to act through 2 main mechanisms: by remodeling high-density lipoproteins (HDL) and by increasing apolipoprotein (apo) B-containing lipoproteins. The aim of this study was to generate a new model of human PLTP transgenic (HuPLTPTg) rabbit and to determine whether PLTP expression modulates atherosclerosis in this species that, unlike humans and mice, displays naturally very low PLTP activity.

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