Dimethylarginine Dimethylaminohydrolase 1 Modulates Endothelial Cell Growth Through Nitric Oxide and Akt | Zendy

Ping Zhang | Zendy; Xinli Hu | Zendy; Xin Xu | Zendy; Yingjie Chen | Zendy; Robert J. Bache | Zendy

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Dimethylarginine Dimethylaminohydrolase 1 Modulates Endothelial Cell Growth Through Nitric Oxide and Akt

Author(s) -

Ping Zhang,

Xinli Hu,

Xin Xu,

Yingjie Chen,

Robert J. Bache

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.215640

Subject(s) - asymmetric dimethylarginine , protein kinase b , soluble guanylyl cyclase , umbilical vein , nitric oxide , phosphorylation , endothelial stem cell , arginine , microbiology and biotechnology , small interfering rna , medicine , chemistry , endocrinology , biology , biochemistry , transfection , guanylate cyclase , amino acid , gene , in vitro

Dimethylarginine dimethylaminohydrolase 1 (DDAH1) modulates NO production by degrading the endogenous nitric oxide (NO) synthase (NOS) inhibitors asymmetrical dimethylarginine (ADMA) and L-NG-monomethyl arginine (L-NMMA). This study examined whether, in addition to degrading ADMA, DDAH1 exerts ADMA-independent effects that influence endothelial function.

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