Serum Hepcidin and Macrophage Iron Correlate With MCP-1 Release and Vascular Damage in Patients With Metabolic Syndrome Alterations | Zendy

Luca Valenti | Zendy; Paola Dongiovanni | Zendy; Benedetta Maria Motta | Zendy; Dorine W. Swinkels | Zendy; P. Bonara | Zendy; Raffaela Rametta | Zendy; Larry Burdick | Zendy; Cecelia Frugoni | Zendy; Anna Ludovica Fracanzani | Zendy; Silvia Fargion | Zendy

Open Access

Serum Hepcidin and Macrophage Iron Correlate With MCP-1 Release and Vascular Damage in Patients With Metabolic Syndrome Alterations

Author(s) -

Luca Valenti,

Paola Dongiovanni,

Benedetta Maria Motta,

Dorine W. Swinkels,

P. Bonara,

Raffaela Rametta,

Larry Burdick,

Cecelia Frugoni,

Anna Ludovica Fracanzani,

Silvia Fargion

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.214858

Subject(s) - hepcidin , medicine , endocrinology , monocyte , hemochromatosis , inflammation , macrophage , ex vivo , metabolic syndrome , cytokine , chemistry , in vitro , obesity , biochemistry

Increased body iron stores and hepcidin have been hypothesized to promote atherosclerosis by inducing macrophage iron accumulation and release of cytokines, but direct demonstration in human cells is lacking. The aim of this study was to evaluate the effect of iron on cytokine release in monocytes ex vivo and the correlation with vascular damage and to evaluate the relationship among serum levels of hepcidin, cytokines, and vascular damage in patients with metabolic syndrome alterations.

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