Neural Crest–Derived Stem Cells Migrate and Differentiate Into Cardiomyocytes After Myocardial Infarction
Author(s) -
Yuichi Tamura,
Keisuke Matsumura,
Motoaki Sano,
Hidenori Tabata,
Kensuke Kimura,
Masaki Ieda,
Takahide Arai,
Yohei Ohno,
Hideaki Kanazawa,
Shinsuke Yuasa,
Ruri Kaneda,
Shinji Makino,
Kazunori Nakajima,
Hideyuki Okano,
Keiichi Fukuda
Publication year - 2011
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.110.214726
Subject(s) - neural crest , stem cell , microbiology and biotechnology , biology , neural stem cell , adult stem cell , medicine , endocrinology , endothelial stem cell , in vitro , embryo , biochemistry
We recently demonstrated that primitive neural crest-derived (NC) cells migrate from the cardiac neural crest during embryonic development and remain in the heart as dormant stem cells, with the capacity to differentiate into various cell types, including cardiomyocytes. Here, we examined the migration and differentiation potential of these cells on myocardial infarction (MI).
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