Open AccessMatrix Metalloproteinase 2 and 9 Dysfunction Underlie Vascular Stiffness in Circadian Clock Mutant Mice
Author(s) -
Ciprian B. Anea,
M. Irfan Ali,
Jessica M. Osmond,
Jennifer C. Sullivan,
David W. Stepp,
Ana M. Merloiu,
R. Daniel Rudic
Publication year - 2010
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.110.214379
Subject(s) - circadian rhythm , matrix metalloproteinase , circadian clock , medicine , mutant , matrix (chemical analysis) , endocrinology , biology , chemistry , biochemistry , gene , chromatography
To determine if elasticity in blood vessels is compromised in circadian clock-mutant mice (Bmal1-knockout [KO] and Per-triple KO) and if matrix metalloproteinases (MMPs) might confer these changes in compliance.
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