Regulation of Functionally Active P2Y12 ADP Receptors by Thrombin in Human Smooth Muscle Cells and the Presence of P2Y12 in Carotid Artery Lesions | Zendy

Bernhard Rauch | Zendy; A Rosenkranz | Zendy; Swen Ermler | Zendy; Andreas Böhm | Zendy; Julia Driessen | Zendy; Jens W. Fischer | Zendy; Atsuhiro Sugidachi | Zendy; Joseph A. Jakubowski | Zendy; Karsten Schrör | Zendy

Open Access

Regulation of Functionally Active P2Y12 ADP Receptors by Thrombin in Human Smooth Muscle Cells and the Presence of P2Y12 in Carotid Artery Lesions

Author(s) -

Bernhard Rauch,

A Rosenkranz,

Swen Ermler,

Andreas Böhm,

Julia Driessen,

Jens W. Fischer,

Atsuhiro Sugidachi,

Joseph A. Jakubowski,

Karsten Schrör

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.213702

Subject(s) - p2y12 , thienopyridine , thrombin , tissue factor , prasugrel , platelet , receptor , medicine , gene knockdown , chemistry , microbiology and biotechnology , endocrinology , biology , clopidogrel , biochemistry , aspirin , coagulation , apoptosis , platelet aggregation

The platelet P2Y12 ADP receptor is a well-known target of thienopyridine-type antiplatelet drugs. This study is the first to describe increased transcriptional expression of a functionally active P2Y12 in response to thrombin in human vascular smooth muscle cells (SMC).

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