Increased Atherosclerosis in Mice With Vascular ATP-Binding Cassette Transporter G1 Deficiency—Brief Report | Zendy

Marit Westerterp | Zendy; Joris Koetsveld | Zendy; Shuiqing Yu | Zendy; Seongah Han | Zendy; Rong Li | Zendy; Ira J. Goldberg | Zendy; Carrie L. Welch | Zendy; Alan R. Tall | Zendy

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Increased Atherosclerosis in Mice With Vascular ATP-Binding Cassette Transporter G1 Deficiency—Brief Report

Author(s) -

Marit Westerterp,

Joris Koetsveld,

Shuiqing Yu,

Seongah Han,

Rong Li,

Ira J. Goldberg,

Carrie L. Welch,

Alan R. Tall

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.212985

Subject(s) - abcg1 , ldl receptor , medicine , biology , endothelial stem cell , aorta , endocrinology , cholesterol , lipoprotein , transporter , biochemistry , atp binding cassette transporter , in vitro , gene

The objective of this study was to investigate the role of vascular ATP-binding cassette transporter G1 (ABCG1) in atherogenesis without a confounding difference in macrophage ABCG1 expression. ABCG1 is highly expressed in macrophages and endothelial cells. ABCG1 preserves endothelial function by maintaining endothelial NO synthase activity and by reducing adhesion molecule expression and monocyte adhesion.

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