Role of Toll-Like Receptor 4 in Intimal Foam Cell Accumulation in Apolipoprotein E–Deficient Mice | Zendy

Mie Higashimori | Zendy; Jeffrey B. Tatro | Zendy; Kathryn J. Moore | Zendy; Michael E. Mendelsohn | Zendy; Jonas Galper | Zendy; Debbie Beasley | Zendy

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Role of Toll-Like Receptor 4 in Intimal Foam Cell Accumulation in Apolipoprotein E–Deficient Mice

Author(s) -

Mie Higashimori,

Jeffrey B. Tatro,

Kathryn J. Moore,

Michael E. Mendelsohn,

Jonas Galper,

Debbie Beasley

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.210971

Subject(s) - foam cell , tlr4 , inflammation , apolipoprotein b , tlr2 , ldl receptor , apolipoprotein e , endocrinology , biology , lesion , receptor , medicine , monocyte , chemistry , lipoprotein , cholesterol , pathology , immunology , biochemistry , disease

Atherosclerosis encompasses a conspicuously maladaptive inflammatory response that might involve innate immunity. Here, we compared the role of Toll-like receptor 4 (TLR4) with that of TLR2 in intimal foam cell accumulation and inflammation in apolipoprotein E (ApoE) knockout (KO) mice in vivo and determined potential mechanisms of upstream activation and downstream action.

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