Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway | Zendy

Hidetaka Ota | Zendy; Masato Eto | Zendy; Mitsunobu R. Kano | Zendy; Tomoaki Kahyo | Zendy; Mitsutoshi Setou | Zendy; Sumito Ogawa | Zendy; Katsuya Iijima | Zendy; Masahiro Akishita | Zendy; Yasuyoshi Ouchi | Zendy

Open Access

Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway

Author(s) -

Hidetaka Ota,

Masato Eto,

Mitsunobu R. Kano,

Tomoaki Kahyo,

Mitsutoshi Setou,

Sumito Ogawa,

Katsuya Iijima,

Masahiro Akishita,

Yasuyoshi Ouchi

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.210500

Subject(s) - enos , senescence , endothelial dysfunction , atorvastatin , protein kinase b , catalase , pravastatin , oxidative stress , nitric oxide synthase , resveratrol , nitric oxide , endothelium , chemistry , pharmacology , endocrinology , medicine , biology , biochemistry , signal transduction , cholesterol

Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) have pleiotropic vascular protective effects besides cholesterol lowering. Recently, experimental and clinical studies have indicated that senescence of endothelial cells is involved in endothelial dysfunction and atherogenesis. Therefore, the present study was performed to determine whether statins would reduce endothelial senescence and to clarify the molecular mechanisms underlying the antisenescent property of statins.

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