Deletion of the High-Density Lipoprotein Receptor Scavenger Receptor BI in Mice Modulates Thrombosis Susceptibility and Indirectly Affects Platelet Function by Elevation of Plasma Free Cholesterol | Zendy

Suzanne J.A. Korporaal | Zendy; Illiana Meurs | Zendy; Arnaud D. Hauer | Zendy; Reeni B. Hildebrand | Zendy; Menno Hoekstra | Zendy; Hugo Ten Cate | Zendy; Domenico Praticò | Zendy; JanWillem N. Akkerman | Zendy; Theo J.C. van Berkel | Zendy; Johan Kuiper | Zendy; Miranda Van Eck | Zendy

Open Access

Deletion of the High-Density Lipoprotein Receptor Scavenger Receptor BI in Mice Modulates Thrombosis Susceptibility and Indirectly Affects Platelet Function by Elevation of Plasma Free Cholesterol

Author(s) -

Suzanne J.A. Korporaal,

Illiana Meurs,

Arnaud D. Hauer,

Reeni B. Hildebrand,

Menno Hoekstra,

Hugo Ten Cate,

Domenico Praticò,

JanWillem N. Akkerman,

Theo J.C. van Berkel,

Johan Kuiper,

Miranda Van Eck

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.210252

Subject(s) - scavenger receptor , medicine , endocrinology , platelet , chemistry , cholesterol , fibrinogen , high density lipoprotein , platelet activation , lipoprotein

Scavenger receptor BI (SR-BI) is a cell surface receptor that promotes the selective uptake of cholesteryl esters from high-density lipoprotein (HDL) by the liver. In mice, SR-BI deficiency results in increased plasma HDL cholesterol levels and enhanced susceptibility to atherosclerosis. The aim of this study was to investigate the role of SR-BI deficiency on platelet function.

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