The Emerging Role of the Thioredoxin System in Angiogenesis | Zendy

Louise Dunn | Zendy; Andrew Buckle | Zendy; John P. Cooke | Zendy; M. Ng | Zendy

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The Emerging Role of the Thioredoxin System in Angiogenesis

Author(s) -

Louise Dunn,

Andrew Buckle,

John P. Cooke,

M. Ng

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.209643

Subject(s) - angiogenesis , txnip , thioredoxin , microbiology and biotechnology , biology , thioredoxin interacting protein , glutaredoxin , cancer research , oxidative stress , biochemistry

Although there have been a multitude of studies, the mechanisms of angiogenesis remain incompletely understood. Increasing evidence suggests that cellular redox homeostasis is an important regulator of angiogenesis. The thioredoxin (TRX) system functions as an endogenous antioxidant that can exert influence over endothelial cell function via modulation of cellular redox status. It has become apparent that the cytosolic TRX1 isoform participates in both canonical and novel angiogenic signaling pathways and may represent an avenue for therapeutic exploitation. Recent studies have further identified a role for the mitochondrial isoform TRX2 in ischemia-induced angiogenesis. TRX-interacting protein (TXNIP ) is the endogenous inhibitor of TRX redox activity that has been implicated in growth factor-mediated angiogenesis. AsTXNIP is strongly induced by glucose, this molecule could be of consequence to disordered angiogenesis manifest in diabetes mellitus. This review will focus on data implicating the TRX system in endothelial cell homeostasis and angiogenesis.

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