Antiallergic Cromones Inhibit Neutrophil Recruitment Onto Vascular Endothelium via Annexin-A1 Mobilization
Author(s) -
Samia Yazid,
Giovanna Leoni,
Stephen J. Getting,
Dianne Cooper,
Egle Solito,
Mauro Perretti,
Roderick J. Flower
Publication year - 2010
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.110.209536
Subject(s) - nedocromil , annexin a1 , myeloperoxidase , annexin , intravital microscopy , nedocromil sodium , chemistry , pharmacology , mast cell , cell adhesion , microbiology and biotechnology , inflammation , microcirculation , immunology , apoptosis , cell , medicine , biology , biochemistry , pathology , respiratory disease , alternative medicine , lung , placebo
To determine whether the inhibitory action of the antiallergic cromone "mast cell stabilizing" drugs on polymorphonuclear leukocyte (PMN) trafficking is mediated through an annexin-A1 (Anx-A1) dependent mechanism.
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