A New Role for the Muscle Repair Protein Dysferlin in Endothelial Cell Adhesion and Angiogenesis | Zendy

Arpeeta Sharma | Zendy; Carol Yu | Zendy; Cleo Leung | Zendy; Andy Trane | Zendy; Marco Lau | Zendy; Soraya Utokaparch | Zendy; Furquan Shaheen | Zendy; Nader Sheibani | Zendy; Pascal Bernatchez | Zendy

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A New Role for the Muscle Repair Protein Dysferlin in Endothelial Cell Adhesion and Angiogenesis

Author(s) -

Arpeeta Sharma,

Carol Yu,

Cleo Leung,

Andy Trane,

Marco Lau,

Soraya Utokaparch,

Furquan Shaheen,

Nader Sheibani,

Pascal Bernatchez

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.208108

Subject(s) - dysferlin , microbiology and biotechnology , angiogenesis , biology , caveolae , chemistry , muscular dystrophy , signal transduction , cancer research , genetics

Ferlins are known to regulate plasma membrane repair in muscle cells and are linked to muscular dystrophy and cardiomyopathy. Recently, using proteomic analysis of caveolae/lipid rafts, we reported that endothelial cells (EC) express myoferlin and that it regulates membrane expression of vascular endothelial growth factor receptor 2 (VEGFR-2). The goal of this study was to document the presence of other ferlins in EC.

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