Endovascular Injury Induces Rapid Phenotypic Changes in Perivascular Adipose Tissue | Zendy

Minoru Takaoka | Zendy; Hiroshi Suzuki | Zendy; Seiji Shioda | Zendy; Kenji Sekikawa | Zendy; Yoshihiko Saito | Zendy; Ryozo Nagai | Zendy; Masataka Sata | Zendy

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Endovascular Injury Induces Rapid Phenotypic Changes in Perivascular Adipose Tissue

Author(s) -

Minoru Takaoka,

Hiroshi Suzuki,

Seiji Shioda,

Kenji Sekikawa,

Yoshihiko Saito,

Ryozo Nagai,

Masataka Sata

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.207175

Subject(s) - adipose tissue , phenotype , medicine , pathology , perivascular space , biology , gene , genetics

Accumulating evidence suggests that adipose tissue not only stores energy but also secretes various bioactive substances called adipocytokines. Periadventitial fat is distributed ubiquitously around arteries throughout the body. It was reported that inflammatory changes in the periadventitial fat may have a direct role in the pathogenesis of vascular diseases accelerated by obesity. We investigated the effect of endovascular injury on the phenotype of perivascular fat.

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