Open AccessNovel Function of Tenascin-C, a Matrix Protein Relevant to Atherosclerosis, in Platelet Recruitment and Activation Under Flow
Author(s) -
Mathieu Schaff,
Nicolas Receveur,
Catherine Bourdon,
Virginie Wurtz,
Cécile V. Denis,
Gertraud Orend,
Christian Gachet,
François Lanza,
P Mangin
Publication year - 2010
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.110.206375
Subject(s) - platelet , integrin , von willebrand factor , platelet membrane glycoprotein , platelet activation , chemistry , platelet adhesiveness , gpvi , microbiology and biotechnology , context (archaeology) , adhesion , glycoprotein ib , immunology , biology , biochemistry , receptor , paleontology , platelet aggregation , organic chemistry
The identification of platelet-reactive proteins exclusively present in atherosclerotic plaques could provide interesting targets for effective and safe antithrombotic strategies. In this context, we explored platelet adhesion and activation to tenascin-C (TN-C), a matrix protein preferentially found within atheroma.
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