microRNA-222 Controls Neovascularization by Regulating Signal Transducer and Activator of Transcription 5A Expression | Zendy

Patrizia Dentelli | Zendy; Arturo Rosso | Zendy; Francesca Orso | Zendy; Cristina Olgasi | Zendy; Daniela Taverna | Zendy; Maria Felice Brizzi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

microRNA-222 Controls Neovascularization by Regulating Signal Transducer and Activator of Transcription 5A Expression

Author(s) -

Patrizia Dentelli,

Arturo Rosso,

Francesca Orso,

Cristina Olgasi,

Daniela Taverna,

Maria Felice Brizzi

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.206201

Subject(s) - microrna , stat protein , neovascularization , microbiology and biotechnology , transcription (linguistics) , transcription factor , transducer , activator (genetics) , biology , signal transduction , cancer research , angiogenesis , medicine , stat3 , genetics , gene , engineering , linguistics , philosophy , electrical engineering

Inflammatory stimuli released into atherosclerotic plaque microenvironment regulate vessel formation by modulating gene expression and translation. microRNAs are a class of short noncoding RNAs, acting as posttranscriptional regulators of protein-coding genes involved in various biological processes, including vascular cell biology. Among them, microRNA-221/222 (miR-221/222) seem to negatively modulate vascular remodeling by targeting different target genes. Here, we investigated their potential contribution to inflammation-mediated neovessel formation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research