Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice | Zendy

Radhika Muzumdar | Zendy; Derek M. Huffman | Zendy; John W. Calvert | Zendy; Saurabh Kumar Jha | Zendy; Yoni Weinberg | Zendy; Lingguang Cui | Zendy; Anjaemkal | Zendy; Gil Atzmon | Zendy; L. Klein | Zendy; Susheel Gundewar | Zendy; Sang Yong Ji | Zendy; Madhav Lavu | Zendy; Benjamin L. Predmore | Zendy; David J. Lefer | Zendy

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Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice

Author(s) -

Radhika Muzumdar,

Derek M. Huffman,

John W. Calvert,

Saurabh Kumar Jha,

Yoni Weinberg,

Lingguang Cui,

Anjaemkal,

Gil Atzmon,

L. Klein,

Susheel Gundewar,

Sang Yong Ji,

Madhav Lavu,

Benjamin L. Predmore,

David J. Lefer

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.205997

Subject(s) - medicine , myocardial infarction , reperfusion injury , ejection fraction , cardiology , ischemia , tetrazolium chloride , apoptosis , ventricular remodeling , evans blue , infarction , pharmacology , endocrinology , heart failure , chemistry , biochemistry

Humanin (HN), an endogenous antiapoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults. We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model of myocardial ischemia and reperfusion.

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