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Ath11, an atherosclerosis susceptibility locus on proximal chromosome 10 (0 to 21 cM) revealed in a cross between apolipoprotein E deficient C57BL/6 (B6) and FVB mice, was recently confirmed in congenic mice. The objectives of this study were to assess how Ath11 affects lesion development and morphology, to determine aortic gene expression in congenics, and to narrow the congenic interval.

arteriosclerosis, thrombosis, and vascular biology

The Mouse Atherosclerosis Locus at Chromosome 10 ( <i>Ath11</i> ) Acts Early in Lesion Formation With Subcongenic Strains Delineating 2 Narrowed Regions

The Mouse Atherosclerosis Locus at Chromosome 10 ( Ath11 ) Acts Early in Lesion Formation With Subcongenic Strains Delineating 2 Narrowed Regions