The Mouse Atherosclerosis Locus at Chromosome 10 ( Ath11 ) Acts Early in Lesion Formation With Subcongenic Strains Delineating 2 Narrowed Regions | Zendy

Susanne Wolfrum | Zendy; José Manuel Rodríguez Rodríguez | Zendy; Marietta Tan | Zendy; Kwan Y. Chen | Zendy; Daniel Teupser | Zendy; Jan L. Breslow | Zendy

Open Access

The Mouse Atherosclerosis Locus at Chromosome 10 ( Ath11 ) Acts Early in Lesion Formation With Subcongenic Strains Delineating 2 Narrowed Regions

Author(s) -

Susanne Wolfrum,

José Manuel Rodríguez Rodríguez,

Marietta Tan,

Kwan Y. Chen,

Daniel Teupser,

Jan L. Breslow

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.205757

Subject(s) - locus (genetics) , biology , genetics , lesion , chromosome , pathology , medicine , gene

Ath11, an atherosclerosis susceptibility locus on proximal chromosome 10 (0 to 21 cM) revealed in a cross between apolipoprotein E deficient C57BL/6 (B6) and FVB mice, was recently confirmed in congenic mice. The objectives of this study were to assess how Ath11 affects lesion development and morphology, to determine aortic gene expression in congenics, and to narrow the congenic interval.

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