Inhibition of Liver X Receptor/Retinoid X Receptor–Mediated Transcription Contributes to the Proatherogenic Effects of Arsenic in Macrophages In Vitro | Zendy

Alessandra M.S. Padovani | Zendy; Manuel Flores Molina | Zendy; Koren K. Mann | Zendy

Open Access

Inhibition of Liver X Receptor/Retinoid X Receptor–Mediated Transcription Contributes to the Proatherogenic Effects of Arsenic in Macrophages In Vitro

Author(s) -

Alessandra M.S. Padovani,

Manuel Flores Molina,

Koren K. Mann

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.205500

Subject(s) - liver x receptor , retinoid x receptor , abca1 , nuclear receptor , arsenic , receptor , retinoid x receptor alpha , transcription factor , efflux , biology , abcg1 , chromatin immunoprecipitation , chemistry , biochemistry , promoter , gene expression , gene , transporter , organic chemistry

To determine whether arsenic inhibits transcriptional activation of the liver X receptor (LXR)/retinoid X receptor (RXR) heterodimers, thereby impairing cholesterol efflux from macrophages and potentially contributing to a proatherogenic phenotype.

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