Characterization of Ion Channels Involved in the Proliferative Response of Femoral Artery Smooth Muscle Cells | Zendy

Pilar Cidad | Zendy; Alejandro MorenoDomínguez | Zendy; Laura Novensà | Zendy; Mercè Roqué | Zendy; Leire Barquín | Zendy; Magda Heras | Zendy; M. Teresa PérezGarcía | Zendy; José R. LópezLópez | Zendy

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Characterization of Ion Channels Involved in the Proliferative Response of Femoral Artery Smooth Muscle Cells

Author(s) -

Pilar Cidad,

Alejandro MorenoDomínguez,

Laura Novensà,

Mercè Roqué,

Leire Barquín,

Magda Heras,

M. Teresa PérezGarcía,

José R. LópezLópez

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.205187

Subject(s) - vascular smooth muscle , phenotype , microbiology and biotechnology , in vivo , hyperplasia , artery , gene expression , ion channel , femoral artery , biology , chemistry , gene , medicine , endocrinology , smooth muscle , receptor , biochemistry , genetics

Vascular smooth muscle cells (VSMCs) contribute significantly to occlusive vascular diseases by virtue of their ability to switch to a noncontractile, migratory, and proliferating phenotype. Although the participation of ion channels in this phenotypic modulation (PM) has been described previously, changes in their expression are poorly defined because of their large molecular diversity. We obtained a global portrait of ion channel expression in contractile versus proliferating mouse femoral artery VSMCs, and explored the functional contribution to the PM of the most relevant changes that we observed.

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