Increased Secretion of Lipoproteins in Transgenic Mice Expressing Human D374Y PCSK9 Under Physiological Genetic Control | Zendy

Bronwen Herbert | Zendy; Dilipkumar Patel | Zendy; Simon N. Waddington | Zendy; Emily R. Eden | Zendy; Alexandra McAleenan | Zendy; XiMing Sun | Zendy; Anne K. Soutar | Zendy

Open Access

Increased Secretion of Lipoproteins in Transgenic Mice Expressing Human D374Y PCSK9 Under Physiological Genetic Control

Author(s) -

Bronwen Herbert,

Dilipkumar Patel,

Simon N. Waddington,

Emily R. Eden,

Alexandra McAleenan,

XiMing Sun,

Anne K. Soutar

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.204040

Subject(s) - pcsk9 , kexin , transgene , genetically modified mouse , ldl receptor , biology , endocrinology , lipoprotein , bacterial artificial chromosome , medicine , cholesterol , mutant , triglyceride , receptor , familial hypercholesterolemia , gene , biochemistry , genome

To produce transgenic mice expressing the D374Y variant of the human proprotein convertase subtilisin/kexin type 9 (PCSK9) gene at physiological levels to investigate the mechanisms causing hypercholesterolemia and accelerated atherosclerosis.

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