Acadesine Inhibits Tissue Factor Induction and Thrombus Formation by Activating the Phosphoinositide 3-Kinase/Akt Signaling Pathway | Zendy

Weiyu Zhang | Zendy; Jianguo Wang | Zendy; Huan Wang | Zendy; Rong Tang | Zendy; John D. Belcher | Zendy; Benoı̂t Viollet | Zendy; Jian-Guo Geng | Zendy; Chunxiang Zhang | Zendy; Chaodong Wu | Zendy; Arne Slungaard | Zendy; Chuhong Zhu | Zendy; Yuqing Huo | Zendy

Open Access

Acadesine Inhibits Tissue Factor Induction and Thrombus Formation by Activating the Phosphoinositide 3-Kinase/Akt Signaling Pathway

Author(s) -

Weiyu Zhang,

Jianguo Wang,

Huan Wang,

Rong Tang,

John D. Belcher,

Benoı̂t Viollet,

Jian-Guo Geng,

Chunxiang Zhang,

Chaodong Wu,

Arne Slungaard,

Chuhong Zhu,

Yuqing Huo

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.203141

Subject(s) - protein kinase b , tissue factor , protein kinase a , activator (genetics) , phosphoinositide 3 kinase , umbilical vein , kinase , pi3k/akt/mtor pathway , signal transduction , pharmacology , chemistry , microbiology and biotechnology , medicine , receptor , biology , coagulation , biochemistry , in vitro

Acadesine, an adenosine-regulating agent and activator of AMP-activated protein kinase, has been shown to possess antiinflammatory activity. This study investigated whether and how acadesine inhibits tissue factor (TF) expression and thrombus formation.

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