Oxygen: Both a Passenger and a Biological Determinant in the Vasculature

Series Editor: Frank Giordano ATVB in Focus Oxygen Sensing Articles in this series: •Giordano F. Oxygen: both a passenger and a biological determinant in the vasculature. Arterioscler Thromb Vasc Biol 2010;30:641–642. •Taylor CT, Moncada S. Nitric oxide, cytochrome c oxidase and the cellular response to hypoxia. Arterioscler Thromb Vasc Biol 2010;30:643–647. •Semenza GL. Vascular responses to hypoxia and ischemia. Arterioscler Thromb Vasc Biol 2010;30:648–652. •Lassegue B, Griendling KK. NADPH oxidases: functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol 2010;30:653–661. •Shoag J, Arany Z. Regulation of hypoxia-inducible genes by PGC-1. Arterioscler Thromb Vasc Biol 2010;30:662–666. Cells have an extensive repertoire of “sensors” that monitor and respond to signals from their internal and external environments. As a fundamental substrate for cellular respiration, crucial biological pathways have developed to sense and respond to oxygen availability. In this Arteriosclerosis, …